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Leprae multiplies at the site of entry usually the skin invading and colonizing schwann cells. The incubation period is 3 15 years. The microbe then induces t helper lymphocytes epithelioid cells and giant cell infiltration of the skin causing infected individuals to exhibit large flattened patches with raised and elevated red edges on their skin.
lepra cells found in lepromatous leprosy are lepra cells found in

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The infection is currently found in over 100 countries often located in high burden areas against a low burden background of cases.

Lepra cells found in. Through this form m. Clinical manifestations are varied and reflect the hosts immune response to the bacteria. Nasal discharge and skin lesion are the sources of infection.

Distinctive large mononuclear phagocytes macrophages with a foamlike cytoplasm and also poorly staining saclike structures resulting from degeneration of such cells observed characteristically in leprous inflammatory reactions. These patches have dry pale hairless centers accompanied by a loss of sensation on the skin. Mycobacterium leprae is the aetiologic agent of leprosy affecting the skin and peripheral nerves.

Skin ears nasal mucosa and peripheral nerves lungs liver testes eyes and bones are also affected. Lepra bacilli prefer lower temperature therefore they localize in superficial cooler tissue ie. Indistinct staining results from numerous fairly closely packed leprosy bacilli which are acid fast and resistant to staining by ordinary methods but may be vividly demonstrated by acid fast staining procedures.

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