Type 2 Lepra Reaction Treatment
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It is clinically presumed.
Type 2 lepra reaction treatment. Treatment for severe type 2 lepra reactions may include. It is also called a lepra 1 reaction. Leprosy is a bacterial infectious disorder that principally affects people in developing countries like brazil india the democratic republic of congo bangladesh and nigeria.
Drugs used in treatment of type ii lepra reaction are. Leprae that initiate a cascade of humoral and cellular responses. Leprosy is a chronic granulomatous infection caused by the organism mycobacterium leprae that primarily affects the skin and peripheral nerves.
Bed rest and drugs such as acetylsalicylic acid corticosteroids nonsteroidal anti inflammatory drug nsaid chloroquine antimony compounds pentoxifylline and thalidomide are used in the treatment 4 24 25. Lasting for 48 72 hours or a few days poor gc mb leprosy. 6 type 1 or reversal reactions are most typical of borderline cases although can occur anywhere along the disease spectrum and occur in 30 of patients.
Second line antileprosy drugs include clarithromycin ofloxacin moxifloxacin and minocycline. The type 1 lepra reaction is a delayed type of hypersensitivity to leprae antigens. Comparative efficacy of four treatment regimens in type 2 leprosy reactions prednisolone alone thalidomide alone prednisolone plus thalidomide and prednisolone plus clofazimine.
1 the organism is thought to be transmitted from person to person via the nasal secretions of infected individuals and is known to have a long incubation period lasting 2 to 6 years. 3 treatment typically involves antimicrobials eg. Increased bacterial load later during treatment eruption of evanescent tender red papules nodules most frequently occur on extremities and face blanch on pressure lymph nodes liver and spleen may be painful and enlarged nerves and joints may become swollen and tender.
Type 2 reactions erythema nodosum leprosum should be treated with thalidomide 100200 mgdaily clofazimine 200 mgdaily and pentoxifylline 800 mgdaily. Suppression of inflammation is the basis of therapy. Prednisone at a dose of about 1 mgkgday quickly tapered clofazimine note that the multibacillary regimen with clofazimine prevents type 2 lepra reactions thalidomide 400 mgday for 510 days tapered over 12 months.
Know about lepra reaction causes symptoms treatment at genericforce. Erythema nodosum leprosum type 2 reaction episodic. Antimicrobial resistance assays must be performed in case of treatment failure or relapse.
Reactions are characterized by immune responses to m. 7 type 2. After the use of clofazimine containing mdt type 2 reaction prevalence has decreased in leprosy patients under therapy.
Relapse and resistance may occur.
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