Type 1 Vs Type 2 Lepra Reaction
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Ulcers are an uncommon presentation of leprosy.
Type 1 vs type 2 lepra reaction. In type 2 the existing lesions become more pronounced more red. 2 type 2 reaction t2r or erythema nodosum leprosum affects patients with the bb bl and lepromatous leprosy ll forms and has been defined as an. Lepra reactions can be a presenting feature in a significant number of new leprosy cases at initial diagnosis.
Type 1 lepra reaction reversal reaction is characterized by the development of acute erythema and swelling of existing skin lesions or by the appearance of new lesions andor neuritis 1 2. Leprosy is also associated with type 1 and type 2 reactions 1. 95 cases of type 2.
Type 2 lepra reaction erythema nodosum leprosum is the appearance of skin nodules due to the immune complexmediated complication of leprosy 3. 4 vasculonecrotic reactions lucio leprosy phenomenon in leprosy are much less common. Type 2 lepra reaction also known as erythema nodosum leprosum enl characteristically presents as nodules over the face arms and legs.
Reversal reaction or lepra type 1 reaction is a delayed type hypersensitivity reaction that arises when borderline leprosy shifts toward borderline lepromatous leprosy with treatment. Type 1 lr t1lr and type 2 lr t2lr are the major causes of nerve damage and permanent disabilities. In the current scenario of leprosy elimination lepra reactions lrs remain a major persistent problem.
Type 1 is mediated by th1 cells and type 2 is mediated by th2 cells. The immunopathogenesis of lr have recently become an important field of research since it may provide the relevant targets for the early detection and control of these episodes. Type 1 reaction t1r or reversal reaction is estimated to result from exacerbation of established or incipient t helper 1 responses presumably triggered by increased release of mycobacteria antigens in immunologically instable forms of the disease borderline tuberculoid bt borderline borderline bb and borderline lepromatous bl.
In lepra reaction type 1 there is widespread new lesions all over the body cause those ag ab reactions get deposited everywhere. Ulnar nerves were the most commonly enlarged nerves in those with type 1 73 and common peroneal in type 2 65. Crops of painful erythematous nodules were seen in 1920.
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