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Type 1 Lepra Reaction Hypersensitivity

Sudden appearance of symptoms. This nerve damage may result in a lack of ability to feel pain which can lead to the loss of parts of a persons extremities from repeated injuries or infection due to unnoticed. Type 1 reaction is a delayed hypersensitivity reaction.
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Type i hypersensitivity or immediate hypersensitivity is an allergic reaction provoked by re exposure to a specific type of antigen referred to as an allergen.

Type 1 lepra reaction hypersensitivity. Involvement of ocular tissue. Reversal reaction or lepra type 1 reaction is a delayed type hypersensitivity reaction that arises when borderline leprosy shifts toward borderline lepromatous leprosy with treatment. Reaction can be the first sign of the disease and it often persists for a few weeks or months 5.

Type i is distinct from type ii type iii and type iv hypersensitivities. Involves ige mediated degranulation of basophils or mast cells. This reaction is always rapid occurring within minutes of exposure to an antigen and always.

It mostly occurs in borderline patients as well as in patients with lepromatous leprosy ll and those with tuberculoid leprosy tl receiving therapy. Swelling of hands feet and pain in small joints. Type 1 reversal reaction acute hypersensitivity to antigens.

Infection can lead to damage of the nerves respiratory tract skin and eyes. Exposure may be by ingestion inhalation injection or direct contact. Leprosy also known as hansens disease hd is a long term infection by the bacteria mycobacterium leprae or mycobacterium lepromatosis.

Inflammation of existing skin lesions or appearance of painful tender nodules. Type 1 lepra reaction reversal reaction is characterized by the development of acute erythema and swelling of existing skin lesions or by the appearance of new lesions andor neuritis 1 2. Type i hypersensitivity reaction is commonly called allergic or immediate hypersensitivity reaction.

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