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Type 1 And 2 Lepra Reaction Difference

Leprosy is also associated with type 1 and type 2 reactions. Autoimmune diseases mediated by direct cellular damage top goldsby et al figure 20 1 hashimotos thyroiditis. These occur as a result of loss of sensation peripheral or very rarely in lepra reaction both type 1 and type 2 reaction and are the presenting features of lucios phenomenon 1 2.
type 1 and 2 lepra reaction difference

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Type 1 reversal and type 2 erythema nodosum leprosum reactions are the 2 main types of leprosy reactions which may affect 30 to 50 of all leprosy patients combined.

Type 1 and 2 lepra reaction difference. On the basis of this they offer a map of the dissemination of leprosy in the world. The first occurs in borderline leprosy bl patients and the latter in lepromatous patients. The type i lepra reaction is usually not associated with systemic features.

Non autoimmune type ii reactions transfusion reactions abo incompatibility hemolytic disease of the newborn erythroblastosis fetalis. Type 1 is mediated by th1 cells and type 2 is mediated by th2 cells. In type 2 the existing lesions become more pronounced more red.

Type 2 lepra reaction also known as erythema nodosum leprosum enl characteristically presents as nodules over the face arms and legs. Strain 3 in europe north africa and the americas. 4 vasculonecrotic reactions lucio leprosy phenomenon in leprosy are much less common.

Strain 1 occurs predominantly in asia the pacific region and east africa. The most important causes of nerve damage are the acute episodes in the chronic course of the disease caused by changes in the host immune response against mycobacterium leprae antigenic determinants known as reactions. Type 2 lepra reaction enl erythema nodosom leprosom is usually associated with constitutional symptoms like fever.

There are type 1 leprosy reaction t1r or reversal reaction and type 2 leprosy reaction t2r also called erythema nodosum leprosum enl. Ifn g lt il 2 il 3 gm csf mif il 8 mcp 1. Reversal reaction or lepra type 1 reaction is a delayed type hypersensitivity reaction that arises when borderline leprosy shifts toward borderline lepromatous leprosy with treatment.

In lepra reaction type 1 there is widespread new lesions all over the body cause those ag ab reactions get deposited everywhere. Strain 4 in west africa and the caribbean. Ulcers are an uncommon presentation of leprosy.

And strain 2 only in ethiopia malawi nepal north india and new caledonia. These distinct conditions occur separately but may arise at different times in the same patient12 it is important to recognise that both these conditions can result in permanent loss of nerve function. Two major complications of leprosy are type 1 reactions t1r and erythema nodosum leprosum enl.

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A Retrospective Analysis Of Histopathology Of 64 Cases Of Lepra Reactions Adhe V Dongre A Khopkar U Indian J Dermatol A Retrospective Analysis Of Histopathology Of 64 Cases Of Lepra Reactions Adhe V Dongre A Khopkar U Indian J Dermatol

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Comparison Between Histopathologic Features Of Leprosy In Reaction Lesions In Hiv Coinfected And Non Coinfected Patients Comparison Between Histopathologic Features Of Leprosy In Reaction Lesions In Hiv Coinfected And Non Coinfected Patients

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Evaluation Of Key Histologic Variables In Skin Biopsies Of Patients Of Borderline Leprosy With Type 1 Lepra Reaction Patnaik N Agarwal S Sharma S Sharma S Pandhi D Indian J Dermatol Source : www.ijdvl.com

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