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Merino Trial Summary

Patients from 26 sites in 9 countries were stratified over a 3 year period february 2014 through july 2017 according to the infecting species presumed source of infection and severity of illness. Study start date. The goal of the trial was to evaluate intravenous antibiotics compared with oral antibiotics among stable patients with infective endocarditis on the left side of the heart.
merino trial summary

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Merino Trial Meropenem Versus Piperacillin Tazobactam For Definitive Treatment Of Bloodstream Infections Due To Ceftriaxone Non Susceptible Escherichia Coli And Klebsiella Spp Patrick N A Harris 1 Updates Research Project

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Actual primary completion date.

Merino trial summary. Coli and klebsiella species. The merino trial offered to overcome some of the discrepancies seen in the previous studies. Merino trial this supplement contains the following items.

Susceptible escherichia coli and klebsiella spp. 11 this study was an international multicenter open label randomized noninferiority trial of ptz 45 g every 6 hours versus meropenem 1 g every 8 hours for the definitive treatment of e coli or k pneumoniae bloodstream infections resistant to ceftriaxone. Randomized controlled trial of meropenem versus piperacillin tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non susceptible e.

Actual study completion date. Findings in this noninferiority randomized clinical trial that included 391 patients with e coli or k pneumoniae bloodstream infection and ceftriaxone resistance the 30 day mortality rate for patients treated with piperacillin tazobactam compared with meropenem was 123 vs 37 respectively. The poet trial showed that oral antibiotics were noninferior to intravenous antibiotics at preventing adverse events.

The merino trial is the first randomized controlled trial to evaluate piperacillintazobactam versus meropenem for the definitive treatment of bsis caused by ceftriaxone not susceptible e coli or k pneumoniae that remained susceptible to piperacillintazobactam by current breakpoints. Original protocol final protocol summary of changes. Listing a study does not mean it has been evaluated by the us.

Save this study trial of meropenem versus piperacillin tazobactam on mortality and clinial response merino ii the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The merino trial is a landmark study published in september of 2018 that investigated piperacillin tazobactam versus meropenem for the treatment of bloodstream infection caused by ceftriaxone resistant e. Original statistical analysis plan final statistical analysis plan summary of changes.

Coli or klebsiella pneumoniae.

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Evaluation Of Empiric B Lactam Susceptibility Prediction Among Enterobacteriaceae By Molecular B Lactamase Gene Testing Journal Of Clinical Microbiology

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Point Counterpoint Piperacillin Tazobactam Should Be Used To Treat Infections With Extended Spectrum Beta Lactamase Positive Organisms Journal Of Clinical Microbiology

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Piperacillin Tazobactam For Esbl Bloodstream Infection Insights From The Merino Trial Infectious Disease Advisor

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Beta Lactam Beta Lactamase Inhibitors Versus Carbapenem For Bloodstream Infections Due To Extended Spectrum Beta Lactamase Producing Enterobacteriaceae Systematic Review And Meta Analysis Sciencedirect

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Table 3 From Treatment Of Infections Caused By Extended Spectrum Beta Lactamase Ampc And Carbapenemase Producing Enterobacteriaceae Semantic Scholar

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Meropenem Versus Piperacillin Tazobactam For Definitive Treatment Of Bloodstream Infections Due To Ceftriaxone Non Susceptible Escherichia Coli And Klebsiella Spp The Merino Trial Study Protocol For A Randomised Controlled Trial

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An Endless One Sided Confidence In Pip Tazo Reflections On Infection Prevention And Control

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Extended Spectrum B Lactamase Producing Enterobacteriaceae Update On Molecular Epidemiology And Treatment Options Springerlink

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What Is The Merino Trial What Are Some Important Things To Know About It An Interview With Lead Investigator Dr Patrick Harris

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Empiric Piperacillin Tazobactam Versus Carbapenems In The Treatment Of Bacteraemia Due To Extended Spectrum Beta Lactamase Producing Enterobacteriaceae

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A Retrospective Analysis Of Risk Factors And Outcomes In Patients With Extended Spectrum Beta Lactamase Producing Escherichia Coli Bloodstream Infections Sciencedirect

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Merino Trial Meropenem Versus Piperacillin Tazobactam For Definitive Treatment Of Bloodstream Infections Due To Ceftriaxone Non Susceptible Escherichia Coli And Klebsiella Spp Patrick N A Harris 1 Updates Research Project

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Adverse Events Risk Associated With Bevacizumab Addition To Breast Cancer Chemotherapy A Meta Analysis Annals Of Oncology

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Effects Of Tranexamic Acid On Death Disability Vascular Occlusive Events And Other Morbidities In Patients With Acute Traumatic Brain Injury Crash 3 A Randomised Placebo Controlled Trial The Lancet

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A Novel Framework To Compare The Effectiveness Of B Lactamase Inhibitors Against Extended Spectrum B Lactamase Producing Enterobacteriaceae Clinical Microbiology And Infection

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Full Article Using B Lactam B Lactamase Inhibitors For Infections Due To Extended Spectrum B Lactamase Producing Enterobacteriaceae To Slow The Emergence Of Carbapenem Resistant Enterobacteriaceae

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Extended Spectrum B Lactamase Producing Enterobacteriaceae Update On Molecular Epidemiology And Treatment Options Springerlink

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Update On Trial Registration 11 Years After The Icmje Policy Was Established Nejm

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Early Treatment With Hydroxychloroquine A Country Based Analysis

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Disease Progression And Treatment Response In Data Driven Subgroups Of Type 2 Diabetes Compared With Models Based On Simple Clinical Features An Analysis Using Clinical Trial Data The Lancet Diabetes Endocrinology

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What Is The Merino Trial What Are Some Important Things To Know About It An Interview With Lead Investigator Dr Patrick Harris

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What Is The Merino Trial What Are Some Important Things To Know About It An Interview With Lead Investigator Dr Patrick Harris

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Empiric Piperacillin Tazobactam Versus Carbapenems In The Treatment Of Bacteraemia Due To Extended Spectrum Beta Lactamase Producing Enterobacteriaceae

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Pdf Meropenem Versus Piperacillin Tazobactam For Definitive Treatment Of Bloodstream Infections Due To Ceftriaxone Non Susceptible Escherichia Coli And Klebsiella Spp The Merino Trial Study Protocol For A Randomised Controlled Trial

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Pdf Resistance Phenotype Prediction From Whole Genome Sequencing Data In Esbl Or Plasmid Ampc Producing E Coli Or K Pneumoniae Results From Bloodstream Isolates Collected During An International Multicentre Randomised Trial The Merino Trial

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The Higher Prevalence Of Extended Spectrum Beta Lactamases Among Escherichia Coli St131 In Southeast Asia Is Driven By Expansion Of A Single Locally Prevalent Subclone Scientific Reports

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What Is The Merino Trial What Are Some Important Things To Know About It An Interview With Lead Investigator Dr Patrick Harris

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Effect Of Treatment Delay On The Effectiveness And Safety Of Antifibrinolytics In Acute Severe Haemorrhage A Meta Analysis Of Individual Patient Level Data From 40 138 Bleeding Patients The Lancet

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