Merino Trial Journal Club
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A total of 23 of 187 patients 123 randomized to piperacillin tazobactam.
Merino trial journal club. The merino trial is a landmark study published in september of 2018 that investigated piperacillin tazobactam versus meropenem for the treatment of bloodstream infection caused by ceftriaxone resistant e. Merino or poet trial. Late afternoonearly evening at an academic medical center.
This has been an ongoing point of debate in the world of gram negative bacilli. 478 women who were randomized appropriately received at least 1 dose of study drug and were included in the primary analysis population 378 997 completed the trial and were assessed for the primary outcome. Clinical question of the day.
Among patients with untreated advanced non small cell lung cancer nsclc with pd l1 expression and without egfr mutations or alk rearrangements does pembrolizumab improve progression free survival compared to platinum based chemotherapy. This equivalent time on study and non study. Whole genome analysis of cephalosporin resistant escherichia coli from bloodstream infections in australia new zealand and singapore.
Overall baseline characteristics between treatment groups were similar except for an increase in diabetes patients in the meropenem group and an increased number of immune compromised patients in the piperacillin tazobactam group. Two id fellows debate. The merino trial offered to overcome some of the discrepancies seen in the previous studies.
High prevalence of cmy 2 producers and st131 carrying blactx m 15 and blactx m 27 published online december 14 2017. Bright young doctors sit in a hospital workroom putting the finishing touches on what are undoubtedly the most comprehensive and yes simply the best consult notes in their respective patients. Among 379 patients mean age 665 years.
Merino trial richard li pharmacy resident antimicrobial stewardshipinfectious diseases learning objectives identify and differentiate between commonly encountered beta lactamases summarize design and present results of the merino trial discuss applicability of not. Official journal of the association of medical microbiology and infectious disease canada. The merino trial provides the best evidence yet that carbapenems are preferable to piperacillin tazobactam for the treatment of serious infections due to esbl producing organisms.
In this interview the lead study investigator provides insights as to their findings and what they have learned through their work. 11 this study was an international multicenter open label randomized noninferiority trial of ptz 45 g every 6 hours versus meropenem 1 g every 8 hours for the definitive treatment of e coli or k pneumoniae bloodstream infections resistant to. Harris pna ben zakour nl roberts lw et al.
No drug at all. Coli or klebsiella pneumoniae.
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