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Merino Trial Jama

The merino trial is a landmark study published in september of 2018 that investigated piperacillin tazobactam versus meropenem for the treatment of bloodstream infection caused by ceftriaxone resistant e. Coli or klebsiella pneumoniae. B twelve patients with meropenem or piperacillin tazobactamresistant organism and 3 with clostridium difficile infection.
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Merino trial this supplement contains the following items.

Merino trial jama. Blbis with carbapenemsthe merino trial. Original protocol final protocol summary of changes. The trial aimed to show that piperacillin tazobactam ptz is non inferior to meropenem for definitive treatment of bacteremia caused by ceftriaxonenon susceptible.

Merino trial investigators and the australasian society for infectious disease clinical research network asid crn. Randomised controlled trial of meropenem versus piperacillin tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non susceptible escherichia coli and klebsiella spp. A clinical and microbiological success defined as survival negative blood cultures temperature of 380c or less and peripheral white blood cell count of less than or equal to 12 000ml to convert to 10 9 l multiply by 0001.

Spp that test susceptible to ptz. The merino trial is the first randomized controlled trial to evaluate piperacillintazobactam versus meropenem for the definitive treatment of bsis caused by ceftriaxone not susceptible e coli or k pneumoniae that remained susceptible to piperacillintazobactam by current breakpoints. Study results were released at the eccmid conference in 2018 and published in.

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