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Merino Trial 2

Such technologies exist including genotypic methods that detect ctx m which based on the merino trial data may be associated with 74 sensitivity or phenotypic mic or disk diffusion methods performed directly from blood culture. Listing a study does not mean it has been evaluated by the us. An interview with lead investigator dr.
merino trial 2

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Merino trial 2. Original protocol final protocol summary of changes. Perus interim president manuel merino is resigning just six days after the impeachment of his predecessor plunged the south american nation into turmoil. 11 this study was an international multicenter open label randomized noninferiority trial of ptz 45 g every 6 hours versus meropenem 1 g every 8 hours for the definitive treatment of e coli or k pneumoniae bloodstream infections resistant to.

A randomised controlled trial comparing two different antibiotics for blood stream infections caused by the escapm group of antibiotic resistant gram negative bacteria. Patrick harris the merino trial is a landmark study published in september of 2018 that investigated piperacillin tazobactam versus meropenem for the treatment of bloodstream infection caused by ceftriaxone resistant e. Blood stream infection caused by bacteria known as escapms an acronum standing for their names.

Overall baseline characteristics between treatment groups were similar except for an increase in diabetes patients in the meropenem group and an increased number of immune compromised patients in the piperacillin tazobactam group. Harris pn peleg ay iredell j et al. The merino trial offered to overcome some of the discrepancies seen in the previous studies.

John mcnamara rachel sieler jill garlick jess. 2 department of microbiology pathology queensland royal brisbane and womens hospital brisbane queensland australia. Randomised controlled trial of meropenem versus piperacillin tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non susceptible escherichia coli and klebsiella spp.

Enterobacter serratia citrobacter providencia and morganella is. Merino trial investigators and the australasian society for infectious disease clinical research network asid crn. Coli or klebsiella pneumoniae.

Study protocol for a randomised controlled trial. Merino trial this supplement contains the following items. Meropenem versus piperacillin tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non susceptible escherichia coli and klebsiella spp the merino trial.

The merino trial screened 1646 patients resulting in a total of 379 patients being included in the final analysis. Save this study trial of meropenem versus piperacillin tazobactam on mortality and clinial response merino ii the safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

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