Lepra Reaction Drugs
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Anti leprosy drugs can be ranked with regard to the bactericidal activity as follows.
Lepra reaction drugs. Data sources include ibm watson micromedex updated 2 nov 2020 cerner multum updated 2 nov 2020 ashp updated 23 oct 2020. Drugs for reactional episodes besides the conventional drugs like prednisolone clofazimine and thalidomide for type 1 and type 2 lepra reactions certain other drugs and combination regimens are now available and some of these include zinc. This material is provided for educational purposes only and is not intended for medical advice diagnosis or treatment.
Allergic reaction or lepra reaction during the course of leprosy immunologically mediated episodes of acute or. Leprosy also known as hansens disease hd is a long term infection by the bacteria mycobacterium leprae or mycobacterium lepromatosis. This nerve damage may result in a lack of ability to feel pain which can lead to the loss of parts of a persons extremities from repeated injuries or infection due to unnoticed.
Five drugs used for treating lepra reactions were analyzed for any variation qualitative in information on various parameters as mentioned in commonly used drug information sources such as cims. The following drug is not used for the treatment of type ii lepra reaction. The early syndrome is a reflection of irritant effect of the drugsubsides with dose adjustment and by taking the drug with meals.
Leprosy can be considered 2 connected diseases that primarily affect superficial tissues especially the skin and peripheral nerves. Zinc given as zinc sulphate formulation 220mgday0 for up to 4 months found to decrease incidence. Leprosy is a chronic infection caused by the acid fast rod shaped bacillus mycobacterium leprae.
Infection can lead to damage of the nerves respiratory tract skin and eyes. This material is provided for educational purposes only and is not intended for medical advice diagnosis or treatment. Rifampin is more bactericidal than dapsone or clofazimine in the current who recommended mdt used to treat leprosy.
C cyclosporine drugs used in treatment of type ii lepra reaction are. Some of the second line anti leprosy drugs are bactericidal for m. Data sources include ibm watson micromedex updated 2 nov 2020 cerner multum updated 2 nov 2020 ashp updated 23 oct 2020.
Gi symptoms enteritis with intermittent loose stools nausea abdominal pain anorexia and weight loss can occur particularly when higher doses are used to control lepra reaction.
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